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Article

Klotho gene polymorphism, brain structure and cognition in early-life development.

Brain imaging and behavior - 1 Feb 2020

de Vries Clarisse F, Staff Roger T, Noble Kimberly G, Muetzel Ryan L, Vernooij Meike W, White Tonya, Waiter Gordon D, Murray Alison D

Abstract excerpt

Variation in the klotho gene is linked to differences in health outcomes: klotho allele KL-VS heterozygosity is associated with longevity, better cognition and greater right frontal grey matter volume in late life. Contradicting reports, however, suggest that KL-VS's effect on health might be age-dependent. Here we examine the relationship between KL-VS genotype, cognition and brain structure in childhood and...

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Source

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Identifiers

PMID: 30393836
DOI: 10.1007/s11682-018-9990-1
PMCID: PMC6588504

Genes

KL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Klotho gene polymorphism, brain structure and cognition in early-life development.PMID 30393836Read ↗

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