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Article

KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical AD

14 Mar 2019

Abstract excerpt

Objective To examine whether the KLOTHO gene variant KL-VS attenuates APOE4-associated β-amyloid (Aβ) accumulation in a late-middle-aged cohort enriched with Alzheimer disease (AD) risk factors. Methods Three hundred nine late-middle-aged adults from the Wisconsin Registry for Alzheimer9s Prevention and the Wisconsin Alzheimer9s Disease Research Center were genotyped to determine KL-VS and APOE4 status and...

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Alzheimer's disease research and treatments
Amyloidosis: Diagnosis, Treatment, Outcomes
Parathyroid Disorders and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30867273
DOI: 10.1212/wnl.0000000000007323

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KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical ADPMID 30867273Read ↗

Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS HeterozygotesSemantic proximity Read ↗

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s diseaseSemantic proximity Read ↗

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.Semantic proximity Read ↗

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.Semantic proximity Read ↗

Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in KLOTHO KL-VS heterozygotes.Semantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau BurdenSemantic proximity Read ↗

KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adultsSemantic proximity Read ↗

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Longevity Klotho gene polymorphism and the risk of dementia in older men.Semantic proximity Read ↗

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