Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders.

Disease models & mechanisms - 27 Aug 2020

Gamache Julia, Yun Young, Chiba-Falek Ornit

Abstract excerpt

The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE on LOAD risk and endophenotypes have yet to be explained. In this Review, we revisit the different aspects of APOE involvement in neurodegeneration and neurological diseases,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Apolipoproteins E
Share to Health Status Disparities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Degeneration

Share to Neurodegenerative Diseases

Share to Risk Assessment

Share to Sex Characteristics

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32859588
DOI: 10.1242/dmm.045211
PMCID: PMC7473656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders.PMID 32859588Read ↗

Age, APOE and sex: Triad of risk of Alzheimer's disease.Semantic proximity Read ↗

Multifaceted roles of APOE in Alzheimer diseaseSemantic proximity Read ↗

The Role of Apolipoprotein E Isoforms in Alzheimer’s DiseaseSemantic proximity Read ↗

Sex-related differences in genetically determined Alzheimer’s diseaseSemantic proximity Read ↗

The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2.Semantic proximity Read ↗

APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's DiseaseSemantic proximity Read ↗

Apolipoprotein E and Alzheimer's diseaseSemantic proximity Read ↗

Multi-functional role of apolipoprotein E in neurodegenerative diseasesSemantic proximity Read ↗

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.Semantic proximity Read ↗

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approachesSemantic proximity Read ↗

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.Semantic proximity Read ↗

Impact of apolipoprotein E isoforms on sporadic Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.