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Article

Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936.

Neurobiology of aging - 1 Jul 2017

de Vries Clarisse F, Staff Roger T, Harris Sarah E, Chapko Dorota, Williams Daniel S, Reichert Polina, Ahearn Trevor, McNeil Christopher J, Whalley Lawrence J, Murray Alison D

Abstract excerpt

A single copy of klotho allele KL-VS is associated with longevity, better health, increased cognition, and bigger regional brain volume. However, its longitudinal effects on cognition and brain volumes, both global and regional, in late life are unclear. In this study we show that, relative to noncarriers, KL-VS heterozygotes had (1) shorter survival; (2) smaller white matter volumes; (3) slower cognitive...

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Identifiers

PMID: 28431289
DOI: 10.1016/j.neurobiolaging.2017.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936.PMID 28431289Read ↗

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Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

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