Article

A termination-independent role of Rat1 in cotranscriptional splicing

2020-07-24

Abstract excerpt

The yeast termination factor Rat1, and its human homolog Xrn2, have been implicated in multiple nuclear processes. Here we report a novel role of Rat1 in mRNA splicing. Rat1 mutants display increased levels of unspliced transcripts. Accumulation of unspliced transcripts was not due to a failure to degrade unspliced mRNA, disruption of termination or an increased elongation rate in Rat1 mutants. ChIP-Seq analysis r...

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Literature Corpus work: 475dd643-ce25-5ef5-afbc-24087ab136df
DOI: 10.1101/2020.07.23.218495

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