Article
Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation.
Nucleic acids research - 1 Feb 2012
Egecioglu Defne E, Kawashima Tadashi R, Chanfreau Guillaume F
Abstract excerpt
The MATa1 gene encodes a transcriptional repressor that is an important modulator of sex-specific gene expression in Saccharomyces cerevisiae. MATa1 contains two small introns, both of which need to be accurately excised for proper expression of a functional MATa1 product and to avoid production of aberrant forms of the repressor. Here, we show that unspliced and partially spliced forms of the MATa1 mRNA are...
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