Article
Cotranscriptional recruitment of the U1 snRNP to intron-containing genes in yeast.
Molecular and cellular biology - 1 Aug 2003
Kotovic Kimberly M, Lockshon Daniel, Boric Lamia, Neugebauer Karla M
Abstract excerpt
Evidence that pre-mRNA processing events are temporally and, in some cases, mechanistically coupled to transcription has led to the proposal that RNA polymerase II (Pol II) recruits pre-mRNA splicing factors to active genes. Here we address two key questions raised by this proposal: (i) whether the U1 snRNP, which binds to the 5' splice site of each intron, is recruited cotranscriptionally in vivo and, (ii) if...
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