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Article

Identification of a regulated pathway for nuclear pre-mRNA turnover.

Cell - 15 Sept 2000

Bousquet-Antonelli C, Presutti C, Tollervey D

Abstract excerpt

We have identified a nuclear pathway that rapidly degrades unspliced pre-mRNAs in yeast. This involves 3'-->5' degradation by the exosome complex and 5'-->3' degradation by the exonuclease Rat1p. 3'-->5' degradation is normally the major pathway and is regulated in response to carbon source. Inhibition of pre-mRNA degradation resulted in increased levels of pre-mRNAs and spliced mRNAs. When splicing was inhibited...

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Identifiers

PMID: 11030620
DOI: 10.1016/s0092-8674(00)00065-9

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