Article
Rapid screening of yeast mutants with reporters identifies new splicing phenotypes.
The FEBS journal - 1 Jun 2013
Dreumont Natacha, Séraphin Bertrand
Abstract excerpt
Nuclear precursor mRNA splicing requires the stepwise assembly of a large complex, the spliceosome. Recent large-scale analyses, including purification of splicing complexes, high-throughput genetic screens and interactomic studies, have linked numerous factors to this dynamic process, including a well-defined core conserved from yeast to human. Intriguingly, despite extensive studies, no splicing defects were...
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