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Article

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

Biochimica et biophysica acta - 1 May 2013

Wojtovich Andrew P, Smith C Owen, Haynes Cole M, Nehrke Keith W, Brookes Paul S

Abstract excerpt

In recent years, it has become apparent that there exist several roles for respiratory complex II beyond metabolism. These include: (i) succinate signaling, (ii) reactive oxygen species (ROS) generation, (iii) ischemic preconditioning, (iv) various disease states and aging, and (v) a role in the function of the mitochondrial ATP-sensitive K(+) (mKATP) channel. This review will address the involvement of complex...

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Identifiers

PMID: 23291191
DOI: 10.1016/j.bbabio.2012.12.007
PMCID: PMC3880126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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