Article

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

2018-02-03

Abstract excerpt

Mitochondrial respiratory complex II utilizes succinate, key substrate of the Krebs cycle, for oxidative phosphorylation, which is essential for glucose metabolism. Mutations of complex II cause cancers and mitochondrial diseases, raising a critical question of the (patho-)physiological functions. To address the fundamental role of complex II in systemic energy metabolism, we specifically knockout SDHB in mice liv...

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Literature Corpus work: 70ea3c8e-0372-5dc3-9df0-efb6c6ef1412
DOI: 10.1101/259226

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