Article

Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of Enhancers

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid-overload may interact with the circadian clock and alter the rhythmicity of gene expression through epigenomic mechanisms in skeletal muscle. Palmitate reprogrammed the circadian transcriptome in myotubes without altering the rhythmic mRNA expression of c...

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Literature Corpus work: 47237f0d-06d7-5ae3-aaab-3ecbf956ae7e
DOI: 10.1101/2021.02.23.432336

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