Article

Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges

2025-10-27

Abstract excerpt

<h4>Background & Aims</h4> PNPLA3(I148M) is the strongest genetic risk factor for steatotic liver disease (SLD), but its functional role and tissue-specific regulation remain unclear. In mice, PNPLA3 is abundant in liver, yet undetectable in adipose depots. Here, we characterize the molecular mechanisms underlying these tissue-specific differences in PNPLA3 expression in mice to clarify its functional role and li...

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Literature Corpus work: b1ead995-be69-5e26-9eb2-d8e11f264e1f
DOI: 10.1101/2025.10.27.684800

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