Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice

26 Jul 2024

Abstract excerpt

The circadian clock system coordinates metabolic, physiological, and behavioral functions across a 24-h cycle, crucial for adapting to environmental changes. Disruptions in circadian rhythms contribute to major metabolic pathologies like obesity and Type 2 diabetes. Understanding the regulatory mechanisms governing circadian control is vital for identifying therapeutic targets. It is well characterized that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Diet and metabolism studies
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39060446
DOI: 10.1007/s00018-024-05364-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese micePMID 39060446Read ↗

DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat dietSemantic proximity Read ↗

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes interventionSemantic proximity Read ↗

Cell-Autonomous and Systemic Circadian Regulation of Gene Expression in AdipocytesSemantic proximity Read ↗

Metabolic resilience is encoded in genome plasticitySemantic proximity Read ↗

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.Semantic proximity Read ↗

Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of EnhancersSemantic proximity Read ↗

Metabolic resilience is encoded in genome plasticitySemantic proximity Read ↗

Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism.Semantic proximity Read ↗

Integrative Analysis of Multi-omics Data Expands Druggable Targets for Circadian MedicineSemantic proximity Read ↗

Androgen-mediated Perturbation of the Hepatic Circadian System Through Epigenetic Modulation Promotes NAFLD in PCOS MiceSemantic proximity Read ↗

Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in MammalsSemantic proximity Read ↗

Histone methylation: at the crossroad between circadian rhythms in transcription and metabolismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.