Article
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism.
Cell metabolism - 7 Oct 2025
Zhou Dishu, Chen Ying, Liu Panpan, Zhu Kun, Holder-Haynes Juliet, Lloyd S Julie-Ann, La Cam Mong, Astapova Inna I, Choa Seunghee, Xiong Ying, Bae Hosung, Aguilar Marlene, Yang Hongyuan, An Yu A, Sun Zheng, Herman Mark A, Gao Xia, Pei Liming, Jang Cholsoon, Rabinowitz Joshua D, Mattar Samer G, Zhang Yongyou, Guan Dongyin
Abstract excerpt
The circadian clock controls 24-h rhythmic processes. However, how genetic variations outside clock genes impact peripheral diurnal rhythms remains largely unknown. Here, we find that genetic variation contributes to different diurnal patterns of hepatic gene expression in both humans and mice. Nutritional challenges alter the rhythmicity of gene expression in mouse liver in a strain-specific manner. Remarkably,...
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