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The Activation of the NF-κB Pathway in Human Adipose-Derived Stem Cells Alters the Deposition of Epigenetic Marks on H3K27 and is Modulated by Fish Oil

2024-10-24

Abstract excerpt

<h4>Background: </h4> Chronic low-grade inflammation in obesity is linked to white adipose tissue (WAT) dysfunction. Plasma lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), triggering NF-κB and worsening these disturbances. Previously, we showed that H3K27 epigenetic modifications affect WAT gene expression in high-fat diet mice, identifying key pathways in adipose-derived stem cells (ASCs). This st...

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Literature Corpus work: 61c4784a-e810-56de-a51f-472249623bfd
DOI: 10.20944/preprints202410.1970.v1

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