Article

Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy

2022-10-28

Abstract excerpt

<title>Abstract</title> <p>Carriers of the R14del pathogenic variant in the phospholamban (<italic>PLN</italic>) gene develop severe cardiomyopathy with extracellular adipocyte infiltration and intracellular cardiomyocyte mitochondrial disturbances. However, the basis of this metabolic dysregulation tailoring potential treatment targets is unknown. Here, we present a combined approach of transcriptional regulatio...

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Literature Corpus work: 2df2cdd2-72a8-5914-bb38-0fc47573f1de
DOI: 10.21203/rs.3.rs-1902254/v1

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