Article

Resistance of E2F4DN to p38 <sup>MAPK</sup> phosphorylation attenuates DNA damage-induced neuronal death via Cited2

2024-10-29

Abstract excerpt

E2F4 is a transcription factor that supports cellular homeostasis and serves as a substrate for the stress-activated kinase p38 MAPK , which phosphorylates it at a conserved Thr248/Thr250 motif. A non-phosphorylatable mutant, E2F4DN (Thr248Ala/Thr250Ala), has shown therapeutic efficacy in a murine model of Alzheimer’s disease (AD). We hypothesized that phosphorylation of E2F4 disrupts its protective function, whe...

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Literature Corpus work: 4723664e-8b1a-56a0-b163-63364a98dc68
DOI: 10.1101/2024.10.29.620791

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Resistance of E2F4DN to p38 <sup>MAPK</sup> phosphorylation attenuates DNA damage-induced neuronal death via Cited2DOI 10.1101/2024.10.29.620791Read

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