E2F4 as a single multifactorial target against Alzheimer’s disease

Abstract excerpt

Alzheimer’s disease (AD) has a multifactorial etiology, which requires a single multi-target approach for an efficient treatment. We have focused on E2F4, a transcription factor that regulates cell quiescence and tissue homeostasis, controls gene networks affected in AD, and is upregulated in the brain of Alzheimer’s patients and of APP swe /PS1 dE9 and 5xFAD transgenic mice. E2F4 contains an evolutionarily-cons...

Topics

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• Alzheimer Disease
• Amyloid beta-Peptides
• Disease Models, Animal
• Genetic Therapy
• Maze Learning
• Mice
• Mice, Transgenic
• Phenotype

Identifiers and source

Literature Corpus work

0bfeeb1e-72b0-5fe0-8dc8-2eae78a55e10

DOI

10.1101/2020.05.08.082784