Article

DNA double-strand break signaling induces aberrant neuronal activity

2026-05-13

Abstract excerpt

<h4>Summary</h4> Aberrant neuronal activity is an early pathological feature of numerous neurodegenerative disorders, including tauopathy, and is thought to play a role in disease progression. However, the mechanism underlying abnormal neuronal activity remains elusive. Here, we reveal a relationship between DNA double-strand break (DSB)/p53 pathway activation and aberrant neuronal activity. Activating p53 as par...

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Literature Corpus work: 30de8aef-aa00-5ea0-bfaa-0c8cbc552f0d
DOI: 10.64898/2026.05.11.724110

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