Article

ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

2023-09-28

Abstract excerpt

Apoptotic neuron death is a key feature of neurodegenerative disease. Considerable efforts have been made to target this pathway but the molecular mechanisms remain incompletely understood. Here, we conducted an unbiased whole genome CRISPR inhibition screen in human neurons to discover genes required for their death and identified known targets including the kinase MAP3K12 (DLK) and the transcription factor JUN....

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Literature Corpus work: e534b8d5-33ed-50d4-9105-1db915625fc6
DOI: 10.1101/2023.09.27.559856

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