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PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response

1 Dec 2022

Abstract excerpt

The p53 transcription factor is a master regulator of cellular stress responses inhibited by repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with pharmacological inhibitors of its repressors is being tested in clinical trials for cancer therapy, but efficacy has been limited by poor induction of tumor cell death. We demonstrate that dual inhibition of MDM2 and PPM1D induces apoptosis in...

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PMID: 36456590
DOI: 10.1038/s41467-022-35089-5

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