HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

Abstract excerpt

<title>Abstract</title> <p>HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates. Biallelic pathogenic sequence variants in the HERC2 gene are associated with HERC2 Angelman-like syndrome. In pathogenic HERC2 variants, complete absence or marked reduction in HERC2 protein levels are observed. The most common pathological v...

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• A549 Cells
• Alternative Splicing
• Binding, Competitive
• Genomics, phytochemicals, and oxidative stress
• Hep G2 Cells
• Kelch-Like ECH-Associated Protein 1
• MCF-7 Cells
• NF-E2-Related Factor 2

Identifiers and source

Literature Corpus work

7c6070a2-f898-5d3e-8fc2-ee4e504122d5

DOI

10.21203/rs.3.rs-1600424/v1