Article
E2F4-Based Gene Therapy Mitigates the Phenotype of the Alzheimer's Disease Mouse Model 5xFAD.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Oct 2021
López-Sánchez Noelia, Garrido-García Alberto, Ramón-Landreau Morgan, Cano-Daganzo Vanesa, Frade José M
Abstract excerpt
After decades of unfruitful work, no effective therapies are available for Alzheimer's disease (AD), likely due to its complex etiology that requires a multifactorial therapeutic approach. We have recently shown using transgenic mice that E2 factor 4 (E2F4), a transcription factor that regulates cell quiescence and tissue homeostasis, and controls gene networks affected in AD, represents a good candidate for a...
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