Article

Stress-Induced <i>PTBP1</i> Reprograms Neuronal Function and Activates Cellular Senescence

2026-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Chronic oxidative stress is a major contributor to neuronal aging. Due to the lack of homologous recombination (HR) DNA damage repair, high oxygen consumption in neurons causes DNA damage accumulation with age, resulting in a decline in neuronal function, senescence-like phenotypes and onset of neurodegenerative diseases. Here, we identify increased PTBP1 as a stress-inducible negative regulato...

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Literature Corpus work: 5ab914b3-295c-53d6-a473-95eebe98c6bf
DOI: 10.64898/2026.04.03.711742

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