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Article

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.

PLoS genetics - 1 Jan 2017

Peel Nina, Iyer Jyoti, Naik Anar, Dougherty Michael P, Decker Markus, O'Connell Kevin F

Abstract excerpt

In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C. elegans homolog of Plk4, ZYG-1, is required for centriole duplication, but our understanding of how ZYG-1 levels are regulated remains incomplete. We have identified the two PP1 orthologs, GSP-1 and GSP-2, and their regulators I-2SZY-2 and...

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PMID: 28103229
DOI: 10.1371/journal.pgen.1006543
PMCID: PMC5289615

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