Article
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
Developmental cell - 1 Dec 2008
Song Mi Hye, Aravind L, Müller-Reichert Thomas, O'Connell Kevin F
Abstract excerpt
Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. Here we show that SZY-20, a putative RNA-binding protein, plays a critical role in limiting centrosome size in C. elegans. SZY-20 localizes in part to centrosomes and in its absence centrosomes possess increased levels of centriolar and pericentriolar components including...
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