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Article

The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo.

Cell - 18 May 2001

O'Connell K F, Caron C, Kopish K R, Hurd D D, Kemphues K J, Li Y, White J G

Abstract excerpt

Centrosome duplication is a critical step in assembly of the bipolar mitotic spindle, but the molecular mechanisms regulating this process during the cell cycle and during animal development are poorly understood. Here, we report that the zyg-1 gene of Caenorhabditis elegans is an essential regulator of centrosome duplication. ZYG-1 is a protein kinase specifically required for daughter centriole formation that...

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Identifiers

PMID: 11371350
DOI: 10.1016/s0092-8674(01)00338-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo.PMID 11371350Read ↗

Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans.Semantic proximity Read ↗

ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles.Semantic proximity Read ↗

The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus.Semantic proximity Read ↗

Protein phosphatase 1 down regulates ZYG-1 levels to limit centriole duplicationSemantic proximity Read ↗

ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.Semantic proximity Read ↗

The Chromatin Remodeling Protein CHD-1 and the EFL-1/DPL-1 Transcription Factor Cooperatively Down Regulate CDK-2 to Control SAS-6 Levels and Centriole NumberSemantic proximity Read ↗

The doublecortin-related gene zyg-8 is a microtubule organizer in Caenorhabditis elegans neurons.Semantic proximity Read ↗

The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.Semantic proximity Read ↗

The anaphase-promoting complex initiates zygote division in Arabidopsis through degradation of cyclin B1.Semantic proximity Read ↗

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.Semantic proximity Read ↗

Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans.Semantic proximity Read ↗

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