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HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice

12 Dec 2023

Abstract excerpt

Aging increases the risk of age-related diseases, imposing substantial healthcare and personal costs. Targeting fundamental aging mechanisms pharmacologically can promote healthy aging and reduce this disease susceptibility. In this work, we employed transcriptome-based drug screening to identify compounds emulating transcriptional signatures of long-lived genetic interventions. We discovered compound 60...

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PMID: 38269100
DOI: 10.1016/j.isci.2023.108681

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