Article
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
Nature - 1 Feb 2022
Reijns Martin A M, Parry David A, Williams Thomas C, Nadeu Ferran, Hindshaw Rebecca L, Rios Szwed Diana O, Nicholson Michael D, Carroll Paula, Boyle Shelagh, Royo Romina, Cornish Alex J, Xiang Hang, Ridout Kate, Schuh Anna, Aden Konrad, Palles Claire, Campo Elias, Stankovic Tatjana, Taylor Martin S, Jackson Andrew P
Abstract excerpt
The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to be mutagenic2,3; however, the impact of transcription-associated mutagenesis remains to be established in higher eukaryotes4. Here we show that ID4-a cancer insertion-deletion (indel) mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.