Article
Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma.
International journal of cancer - 1 Sept 2023
Gielniewski Bartlomiej, Poleszak Katarzyna, Roura Adria-Jaume, Szadkowska Paulina, Jacek Karol, Krol Sylwia K, Guzik Rafal, Wiechecka Paulina, Maleszewska Marta, Kaza Beata, Marchel Andrzej, Czernicki Tomasz, Koziarski Andrzej, Zielinski Grzegorz, Styk Andrzej, Kawecki Maciej, Szczylik Cezary, Czepko Ryszard, Banach Mariusz, Kaspera Wojciech, Szopa Wojciech, Bujko Mateusz, Czapski Bartosz, Zabek Miroslaw, Iżycka-Świeszewska Ewa, Kloc Wojciech, Nauman Pawel, Cieslewicz Joanna, Grajkowska Wieslawa, Morosini Natalia, Noushmehr Houtan, Wojtas Bartosz, Kaminska Bozena
Abstract excerpt
High-grade gliomas are aggressive, deadly primary brain tumors. Median survival of patients with glioblastoma (GBM, WHO grade 4) is 14 months and <10% of patients survive 2 years. Despite improved surgical strategies and forceful radiotherapy and chemotherapy, the prognosis of GBM patients is poor and did not improve over decades. We performed targeted next-generation sequencing with a custom panel of 664 cancer-...
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