Article
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022
Boot Arnoud, Liu Mo, Stantial Nicole, Shah Viraj, Yu Willie, Nitiss Karin C, Nitiss John L, Jinks-Robertson Sue, Rozen Steven G
Abstract excerpt
Topoisomerases nick and reseal DNA to relieve torsional stress associated with transcription and replication and to resolve structures such as knots and catenanes. Stabilization of the yeast Top2 cleavage intermediates is mutagenic in yeast, but whether this extends to higher eukaryotes is less clear. Chemotherapeutic topoisomerase poisons also elevate cleavage, resulting in mutagenesis. Here, we describe p.K743N...
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