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Article

Single-cell detection of copy number changes reveals dynamic mechanisms of adaptation to antifungals in Candida albicans.

Nature microbiology - 1 Nov 2024

Zhou Xin, Hilk Audrey, Solis Norma V, Scott Nancy, Beach Annette, Soisangwan Natthapon, Billings Clara L, Burrack Laura S, Filler Scott G, Selmecki Anna

Abstract excerpt

Genomic copy number changes are associated with antifungal drug resistance and virulence across diverse fungal pathogens, but the rate and dynamics of these genomic changes in the presence of antifungal drugs are unknown. Here we optimized a dual-fluorescent reporter system in the diploid pathogen Candida albicans to quantify haplotype-specific copy number variation (CNV) and loss of heterozygosity (LOH) at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39227665
DOI: 10.1038/s41564-024-01795-7
PMCID: PMC11524788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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