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Article

Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.

The EMBO journal - 2 Jun 2003

Uhl M Andrew, Biery Matt, Craig Nancy, Johnson Alexander D

Abstract excerpt

Candida albicans is the most prevalent human fungal pathogen. Here, we take advantage of haploinsufficiency and transposon mutagenesis to perform large-scale loss-of-function genetic screen in this organism. We identified mutations in 146 genes that affect the switch between its single-cell (yeast) form and filamentous forms of growth; this switch appears central to the virulence of C.albicans. The encoded...

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Identifiers

PMID: 12773383
DOI: 10.1093/emboj/cdg256
PMCID: PMC156753

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Source receipt: pubmed, retrieved 7 Sept 2026.

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