Article

Targeted loss of heterozygosity in <i>Candida albicans</i> using CRISPR-Cas9

2025-05-13

Abstract excerpt

The diploid genome of the fungal pathogen Candida albicans is highly heterozygous, with most allele pairs diverging at either the coding or regulatory level. When faced with selection pressure like antifungal exposure, this hidden genetic diversity can provide a reservoir of adaptive mutations through loss of heterozygosity (LOH) events. Validating the potential phenotypic impact of LOH events observed in clinica...

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Literature Corpus work: e013af93-80ef-587e-b9ed-107697237326
DOI: 10.1101/2025.05.13.653461

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