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Article

Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease.

Journal of neurochemistry - 1 Nov 2015

Deusser Janina, Schmidt Stefanie, Ettle Benjamin, Plötz Sonja, Huber Sabine, Müller Christian P, Masliah Eliezer, Winkler Jürgen, Kohl Zacharias

Abstract excerpt

Parkinson's disease, neuropathologically defined by the aggregation of α-synuclein, is characterized by neuropsychiatric symptoms such as depression and anxiety preceding the onset of motor symptoms. A loss of serotonergic neurons or their projections into the hippocampus and alterations in serotonin release may be linked to these symptoms. Here, we investigate the effect of human A53T α-synuclein on serotonergic...

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Identifiers

PMID: 26201615
DOI: 10.1111/jnc.13253
PMCID: PMC4943922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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