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Article

Next-generation CRISPR gene-drive systems using Cas12a nuclease.

Nature communications - 12 Oct 2023

Sanz Juste Sara, Okamoto Emily M, Nguyen Christina, Feng Xuechun, López Del Amo Víctor

Abstract excerpt

One method for reducing the impact of vector-borne diseases is through the use of CRISPR-based gene drives, which manipulate insect populations due to their ability to rapidly propagate desired genetic traits into a target population. However, all current gene drives employ a Cas9 nuclease that is constitutively active, impeding our control over their propagation abilities and limiting the generation of...

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Identifiers

PMID: 37821497
DOI: 10.1038/s41467-023-42183-9
PMCID: PMC10567717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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