Article

Rock inhibitors target <i>SRSF2</i> leukemia by disrupting cell mitosis and nuclear morphology

2022-02-17

Abstract excerpt

Spliceosome machinery mutations are common early mutations in myeloid malignancies, however effective targeted therapies against them are still lacking. In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified ROCK inhibitors (ROCKi) as selective inhibitors of SRSF2 mutants. ROCKi targeted SRSF2 Mut primary human samples in a xenografts model...

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Literature Corpus work: 46d94059-f14a-55ef-9b0a-c043eaa985e3
DOI: 10.1101/2022.02.15.479934

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