Article

Sensitivity to ATR–CHK1 pathway inhibition in AML/MDS is enhanced by <i>SRSF2</i> mutations and reduced by RUNX1 loss

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> SRSF2 mutations occur in up to 25% of acute myeloid leukemia (AML) and 17% of myelodysplastic syndrome (MDS) cases and are associated with poor prognosis, yet no mutation-directed therapy exists. Here, we aimed to identify therapeutically targetable vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensitivity testing of bone marrow cells from AML patients and healthy donors showed...

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Literature Corpus work: 2e5622da-f001-5873-ac92-28a8f6b9555a
DOI: 10.1101/2025.10.06.680457

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