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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

7 Jul 2021

Abstract excerpt

The spindle assembly checkpoint (SAC) functions as a sensor of unattached kinetochores that delays mitotic progression into anaphase until proper chromosome segregation is guaranteed. 1 , 2 Disruptions to this safety mechanism lead to genomic instability and aneuploidy, which serve as the genetic cause of embryonic demise, congenital birth defects, intellectual disability, and cancer. 3 , 4 However, despite the...

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PMID: 34237269
DOI: 10.1016/j.cub.2021.06.030

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