Article

A mitochondrial surveillance mechanism activated by <i>SRSF2</i> mutations in hematologic malignancies

2023-06-25

Abstract excerpt

Splicing factor mutations are common in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), but how they alter cellular functions is unclear. We show that the pathogenic SRSF2 P95H/+ mutation disrupts the splicing of mitochondrial mRNAs, impairs mitochondrial complex I function, and robustly increases mitophagy. We also identified a mitochondrial surveillance mechanism by which mitochondrial dysfunc...

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Literature Corpus work: 63a7ef34-ab5f-5502-b83a-3bd528bb16e2
DOI: 10.1101/2023.06.25.546449

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