SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

doi:10.1038/s41467-021-25260-9

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Article

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

Nature communications - 13 Sept 2021

Xue Yibo, Morris Jordan L, Yang Kangning, Fu Zheng, Zhu Xianbing, Johnson Fraser, Meehan Brian, Witkowski Leora, Yasmeen Amber, Golenar Tunde, Coatham Mackenzie, Morin Geneviève, Monast Anie, Pilon Virginie, Fiset Pierre Olivier, Jung Sungmi, Gonzalez Anne V, Camilleri-Broet Sophie, Fu Lili, Postovit Lynne-Marie, Spicer Jonathan, Gotlieb Walter H, Guiot Marie-Christine, Rak Janusz, Park Morag, Lockwood William, Foulkes William D, Prudent Julien, Huang Sidong

Abstract excerpt

Inactivating mutations in SMARCA4 and concurrent epigenetic silencing of SMARCA2 characterize subsets of ovarian and lung cancers. Concomitant loss of these key subunits of SWI/SNF chromatin remodeling complexes in both cancers is associated with chemotherapy resistance and poor prognosis. Here, we discover that SMARCA4/2 loss inhibits chemotherapy-induced apoptosis through disrupting intracellular organelle...

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Identifiers

PMID: 34518526
DOI: 10.1038/s41467-021-25260-9
PMCID: PMC8438089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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