Article

Dysregulation of murine long non-coding single cell transcriptome in non-alcoholic steatohepatitis and liver fibrosis

2022-12-27

Abstract excerpt

<h4>Summary</h4> LncRNAs are typified by low expression, nuclear enrichment, high tissue-specificity and functional diversity, but the vast majority are uncharacterized. Here, we develop a catalog of 48,000 mouse liver-expressed lncRNAs and use to elucidate lncRNA dysregulation in high fat diet-induced non-alcoholic steatohepatitis and carbon tetrachloride-induced liver fibrosis by single cell RNA-seq. LncRNA zon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7eac1fa5-239f-5b33-b191-2915f5a66770
DOI: 10.1101/2022.12.26.521944

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of murine long non-coding single cell transcriptome in non-alcoholic steatohepatitis and liver fibrosisDOI 10.1101/2022.12.26.521944Read

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liverSemantic proximity Read

A single-cell transcriptomic atlas characterizes liver non-parenchymal cells in healthy and diseased miceSemantic proximity Read

Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic PotentialSemantic proximity Read

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read

Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Single‐cell transcriptome analysis of aging mouse liverSemantic proximity Read

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver diseaseSemantic proximity Read

Microanatomy of the metabolic associated fatty liver disease (MAFLD) by Single- Cell TranscriptomicsSemantic proximity Read

A Single Cell Gene Expression Atlas of 28 Human LiversSemantic proximity Read

Long Noncoding RNAs and Human Liver DiseaseSemantic proximity Read

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD ProgressionSemantic proximity Read

Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosisSemantic proximity Read