Article

Structural and functional dissection of ASCT2 interaction with Syncytin-1 mediating cell-cell fusion

2026-06-24

Abstract excerpt

<title>Abstract</title> <p>ASCT2 is a neutral amino acid transporter that also serves as the cellular receptor for Syncytin-1, a retroviral envelope gene co-opted for placentation in humans. Although the closely related transporter ASCT1 shares high sequence similarity and the same trimeric architecture, it does not support Syncytin-1–mediated cell–cell fusion, and the molecular basis of receptor specificity has...

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Literature Corpus work: 46c781f2-7982-513a-8ba1-b1a273031212
DOI: 10.21203/rs.3.rs-9860868/v1

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