Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placenta

21 Oct 2024

Abstract excerpt

Syncytin-1, a human fusogenic protein of retroviral origin, is crucial for placental syncytiotrophoblast formation. To mediate cell-to-cell fusion, Syncytin-1 requires specific interaction with its cognate receptor. Two trimeric transmembrane proteins, Alanine, Serine, Cysteine Transporters 1 and 2 (ASCT1 and ASCT2), were suggested and widely accepted as Syncytin-1 cellular receptors. To quantitatively assess the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pregnancy and preeclampsia studies
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39432789
DOI: 10.1073/pnas.2407519121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Receptor usage of Syncytin-1: ASCT2, but not ASCT1, is a functional receptor and effector of cell fusion in the human placentaPMID 39432789Read ↗

Structural and functional dissection of ASCT2 interaction with Syncytin-1 mediating cell-cell fusionSemantic proximity Read ↗

The role of syncytins in human reproduction and reproductive organ cancersSemantic proximity Read ↗

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2Semantic proximity Read ↗

A novel human endogenous retroviral protein inhibits cell-cell fusionSemantic proximity Read ↗

Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formationSemantic proximity Read ↗

Endogenous retroviral syncytin: compilation of experimental research on syncytin and its possible role in normal and disturbed human placentogenesisSemantic proximity Read ↗

Heterologous Avian System for Quantitative Analysis of Syncytin-1 Interaction with ASCT2 ReceptorSemantic proximity Read ↗

Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.Semantic proximity Read ↗

Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentationSemantic proximity Read ↗

Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its actionSemantic proximity Read ↗

TFEB controls syncytiotrophoblast differentiationSemantic proximity Read ↗

Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 VaccinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.