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Article

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2

6 Nov 2008

Abstract excerpt

Syncytin-2 is an envelope gene from the human endogenous retrovirus FRD (HERV-FRD) co-opted by an ancestral primate host, conserved in evolution over >40 Myr, specifically expressed in the placenta, and with a cell-cell fusogenic activity likely contributing to placenta morphogenesis. Here, using the GeneBridge4 human/Chinese hamster radiation hybrid panel, we mapped and identified the human receptor for...

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PMID: 18988732
DOI: 10.1073/pnas.0807413105

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