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Article

A novel human endogenous retroviral protein inhibits cell-cell fusion

15 Mar 2013

Abstract excerpt

While common in viral infections and neoplasia, spontaneous cell-cell fusion, or syncytialization, is quite restricted in healthy tissues. Such fusion is essential to human placental development, where interactions between trophoblast-specific human endogenous retroviral (HERV) envelope proteins, called syncytins, and their widely-distributed cell surface receptors are centrally involved. We have identified the...

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PMID: 23492904
DOI: 10.1038/srep01462

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