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Article

Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2.

Cell adhesion & migration - 3 Mar 2016

Cui Lina, Wang Huiying, Lu Xiaoyin, Wang Rui, Zheng Ru, Li Yue, Yang Xiaokui, Jia Wen-Tong, Zhao Yangyu, Wang Yongqing, Wang Haibin, Wang Yan-Ling, Zhu Cheng, Lin Hai-Yan, Wang Hongmei

Abstract excerpt

The placental syncytiotrophoblast, which is formed by the fusion of cytotrophoblast cells, is indispensable for the establishment and maintenance of normal pregnancy. The human endogenous retrovirus envelope glycoprotein syncytin-2 is the most important player in mediating trophoblast cell-cell fusion as a fusogen. We constructed expression plasmids of wild-type and 21 single-amino-acid substitution mutants of...

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Identifiers

PMID: 26853155
DOI: 10.1080/19336918.2015.1093720
PMCID: PMC4853038

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