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Article

N-Myc–mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer

1 Jul 2019

Abstract excerpt

Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration resistant prostate cancers become androgen receptor (AR) signaling-independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of...

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PMID: 31260412
DOI: 10.1172/jci127961

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