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Article

Polycomb-mediated silencing in neuroendocrine prostate cancer

2 Apr 2015

Abstract excerpt

BACKGROUND: Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the lack of suitable pre-clinical models has hampered previous efforts to develop novel therapeutic strategies. Addressing this need, we have recently established the first in vivo model of complete...

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PMID: 25859291
DOI: 10.1186/s13148-015-0074-4

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